What is PRP?
The PRP method can be defined in detail as the application of thrombocyte and growth factors-rich plasma (Platelet-Rich Plasma) to organs and/or tissues for treatment. It has been used for a long time to help tissue and organ repair in the treatment of various injuries, especially in branches such as orthopedics, plastic reconstructive and aesthetic surgery, and medical aesthetics.
In the PRP method, the blood taken from the patient is separated by a special process and plasma is obtained. The obtained plasma is rich in platelets, whose main function in the body is blood coagulation. This plasma is given back to the patient by injection. Platelets help cell regeneration with the growth factors they contain. Thanks to the PRP process, a natural rejuvenation is achieved without giving foreign substances and drugs to the body with 3-4 applications at intervals of 2-4 weeks.
PRP Method in IVF Treatment
IVF treatment gives couples the chance to have a baby naturally and/or with various assisted reproductive treatments. Especially in women, problems such as ovulation disorders and infertility can be seen in advanced age. If the desired success rate is not achieved despite the attempts for pregnancy, some support applications may be needed. The PRP method, which is used for tissue and organ regeneration in different branches, has been used for different problems such as infertility, ovarian rejuvenation, and removal of intrauterine membrane problems in the IVF process in recent years. With PRP application, couples who normally have a low chance of pregnancy may also have a higher chance of conceiving. Researches on PRP in the field of IVF; It is shown that the support given by the application of PRP obtained from the patient's own blood to the uterine membrane in addition to the ongoing treatment increases the success of pregnancy in patients whose uterine membrane thickness is thinner than necessary during IVF treatment.
PRP application in the IVF treatment process can basically be defined as the process of returning the platelet-rich blood obtained from the patient's own blood to the patient's uterus. In addition to bringing the uterine lining to the appropriate thickness, it can also be used to improve poor ovarian reserve and increase egg quality.
To Whom Can PRP Method Be Applied in In Vitro Fertilization (IVF) Treatment?
One of the most important parameters that increase the chance of conception in IVF treatment is the number of eggs and egg quality of the woman. One of the most important factors affecting egg reserve is age. When the woman's age is over 37, the number of eggs decreases rapidly. Some women under the age of 40 may also have a rapid decrease in the number of eggs due to early menopause. Pregnancy can be achieved with in vitro fertilization treatment in women with reduced egg count. With the application of PRP to the ovaries in women with a history of early menopause in women with reduced egg number and in women with poor egg and embryo quality, the chance of pregnancy can be increased by providing positive effects on the number and quality of eggs.
Another area where the PRP method is used in IVF is the uterine lining. In case of damage to the endometrium (it may be damaged due to injections, recurrent curettage procedures or intrauterine surgeries), this layer does not thicken and a condition called thin endometrium occurs. Since the thin endometrium prevents the embryo from adhering to in vitro fertilization, patients cannot become pregnant. In these patients with recurrent IVF failure, the adhesion (synechia) can be opened with hysteroscopy and endometrial thickening can be achieved with repetitive endometrial PRP applications. Pregnancy is possible.
If we say that the PRP method can be applied to whom,
In women who have problems such as Wall of womb thickness and egg quality,
In those who fail in one or more IVF treatment attempts,
In women with reduced ovarian reserve,
It can be applied to women who are undergoing IVF treatment at an advanced age.
How is PRP Method Applied in IVF Treatments?
OVARIAN PRP: PRP injection is made by entering the ovaries with an opu needle, just like the egg collection process. Positive effects can be achieved on the number and quality of eggs.
ENDOMETRIAL PRP: It is the prp procedure performed in the uterus. It can increase endometrial thickening in patients with thin endometrium in which the endometrium (the inner layer of the uterus) does not thicken and facilitate the attachment of the embryo, and increase the chance of pregnancy in women with recurrent IVF failure.
What are the Examination and Workup in PRP Method?
Before the PRP application, ultrasound examination and tests are performed to observe the ovarian reserve and intrauterine findings of the woman and the thickness of the uterus. After these examinations and tests, the PRP method can be planned if there is a suitable candidate.
How to Follow Up After PRP Application?
Women who experience menstrual irregularity after the application may be recommended to use menstrual-regulating drugs.
After the application, control is carried out in the second menstrual period or in the first menstrual period according to the follow-up and decision of the physician. During this examination, the ovaries and follicular are examined.